The medical name for the drug: Cardioselective beta1-blocker.

Metoprolol - has little membrane stabilizing effect, has no intrinsic sympathomimetic activity.

It has an anti hypertensive, antianginal and antiarrhythmic action.

  • Metoprolol. Blocks beta1-adrenergic receptors of the heart;
  • reduces the formation of cyclic AMP from adenosine triphosphate;
  • drug reduces intracellular calcium current;
  • It reduces the heart rate;
  • inhibits the conductivity and excitability;
  • reduces myocardial contractility;

Anti-hypertensive effect Metoprolol medication caused a reflex decrease in cardiac output and renin synthesis:

  • inhibition of the renin-angiotensin-aldosterone system;
  • central nervous system;
  • restoration of the sensitivity of baroreceptors of the aortic arch;
  • decrease peripheral sympathetic influences;

It reduces high blood pressure at rest and during exercise. Anti-hypertensive effect develops rapidly, blood pressure is reduced by 15 minutes. Effect lasts for 6 hours and diastolic blood pressure changes slower. Stable decrease was observed after a few weeks of regular intake.

Antianginal effect of the drug is determined by Metoprolol decrease myocardial oxygen demand by reducing heart rate. Metoprolol reduces the number and severity of angina attacks and increase exercise tolerance. Due to the increase in diastolic pressure in the left ventricle and increase the tension of muscle fibers of the ventricles can increase myocardial oxygen demand, especially in patients with chronic heart failure.

When tachycardia, atrial fibrillation, sinus tachycardia - could lead to the restoration of the rhythm. The drug reduces the risk of the development of a migraine! In contrast, nonselective beta-blockers Metoprolol, has a less pronounced effect on the organs when used in high therapeutic doses. When used in high doses (more than 100 mg per day) blocks beta1- and beta2-adrenergic receptors!
Absorption in the gastro-intestinal tract when taken orally, approximately (95%). Solubility in fats moderate. It is extensively metabolized systemic bioavailability - (50%) at the first reception and to increase (70%) with repeated use.
Communication with the plasma proteins around (10%). Time to maximum concentration Metoprolol 1,5 - 2:00. During the course of treatment increases the bioavailability of the drug. Eating increases bioavailability (20-40%). Metoprolol is rapidly distributed into the tissues and penetrate the blood-brain barrier, the placental barrier. Easily passes into breast milk.

It is metabolized in the liver, two metabolites possess beta adrenoblokiruyuschey activity. The metabolism of the drug is involved isozyme CYP2D6. The half-life is between Metoprolol (3.5 to 7 hours) at intake.

The bioavailability is increased by liver failure, this can reduce the total clearance of the drug.

Indications for use Metoprolol:

  • arterial hypertension;
  • functional cardiac abnormalities, accompanied by tachycardia;
  • cardiac ischemia;
  • prevention of angina attacks;
  • cardiac arrhythmias supraventricular tachycardia;
  • ventricular premature beats;
  • hyperthyroidism;
  • prevention of migraine attacks;
  • Contraindications to the use Metoprolol:
  • hypersensitivity to Metoprolol, other ingredients or other beta-blockers;
  • cardiogenic shock;
  • acute and chronic heart failure in the stage of decompensation;
  • angina pectoris, acute myocardial infarction;
  • concomitant use of monoamine oxidase inhibitors;
  • lactose intolerance;
  • lactase deficiency and syndrome of glucose-galactose malabsorption;
  • severe peripheral circulatory disorders;
  • severe bronchial asthma or bronchospasm in history;
  • age of 18 years;
  • lactation;

If you want to buy Metoprolol medication, discuss this with your doctor. Do not take and do not buy this drug without consulting a pharmacist. If you need to purchase this medication, you can order it online, without a prescription. To do this, you can click on an advertising link on the proven online pharmacy.

Dosage and administration Metoprolol:

Inside, during or immediately after a meal, the tablet can be divided in half (do not chew), a liquid drink not less than 200 grams.
When hypertension (in combination with other antihypertensives) an initial dose of 50-100 mg (morning and evening) with insufficient therapeutic effect, the daily dose may be increased to 100-200 mg.

The maximum daily dose of Metoprolol - 200 mg.

Elderly patients are recommended to start treatment with 50 mg per day. Coronary heart disease: heart attack (secondary prevention) - 200 mg per day, in 2 divided doses (morning and evening). Prevention of angina attacks, heart rhythm disturbances 100-200 mg 1-2 times a day (morning and evening).

In hyperthyroidism 50 mg 2 times a day (morning and evening). Prophylaxis of migraine attacks 100-200 mg 1-2 times a day (morning and evening).

With care take Metoprolol:

  • diabetes mellitus;
  • asthma;
  • chronic obstructive pulmonary disease;
  • renal or hepatic impairment;
  • depression;
  • psoriasis;
  • pregnancy;
  • elderly age;

Overdose drug Metoprolol:

  • dizziness;
  • lowering blood pressure;
  • fainting;
  • arrhythmia;
  • heart failure;
  • heart failure;
  • loss of consciousness;
  • nausea;
  • vomiting;
  • convulsions;

The first signs of overdose appear within 20 minutes - 2 hours after ingestion.

In mild overdose of Metoprolol is used such methods of treatment:

  • gastric lavage;
  • reception absorbent medicines;

In case of overdose the patient's life-threatening, requires urgent hospitalization!

Pregnancy, lactation:
During pregnancy, prescribed only on strict conditions if the expected benefit to the mother outweighs the potential risk to the fetus. Treatment should be interrupted for 48-72 hours before delivery. In cases where this is not possible, it is necessary to ensure strict monitoring of the newborn for 48 - 72 hours after delivery. Metoprolol passes into breast milk, the drug should not be taken during lactation or during the treatment of mother should stop breastfeeding.

Effects on ability to drive and use dangerous machinery: During treatment, Metoprolol should be careful when driving and occupation of other potentially hazardous activities that require high concentration and psychomotor speed reactions.

The drug Metoprolol You can buy online (without a prescription) - if you will pass on the advertising link in the online pharmacy.