Buy Avodart-Dutasteride online

Avodart Dutasteride

If you do not know where to buy Dutasteride (Avodart) - on this site you will find advertisements proven online pharmacies can buy the drug without a prescription.

The drug Dutasteride can be found in pharmacies under such names:
Avodart, Avidart, Duagen, Duodart, Duprost, Dutasterid, Dutasterida, Dutasteridum, Zytefor.

Pharmacological properties:

Dutasteride - an inhibitor of 5-α-reductase inhibitor, inhibits both type 1 and type 2 isozymes of 5-α-reductase, responsible for the conversion of testosterone to 5-α-dihydrotestosterone.

Dihydrotestosterone - androgen primarily responsible for prostatic hyperplasia tissue. The maximum decrease DHT while taking Avodart is dose dependent and is observed in the first and second week. After the 1st and 2nd weeks Avodart treatment in a daily dose of 0.5 mg average dihydrotestosterone concentration is reduced by 85 and 90%.

Patients with benign prostatic hyperplasia, Dutasteride treated with 0.5 mg per day, the average reduction in DHT was 94% at 1 year and 93% - after 2 years of treatment, mean testosterone levels increased by 19% after 1 and 2 years. This is the expected consequence of inhibition of 5-α-reductase, and it does not lead to the expression of various known side effects.

According to the multi-pivot placebo-controlled, double-blind clinical trials involving 4330 men with benign prostatic hyperplasia (> 30 cm3), application buy Avodart 0.5 mg per day resulted in a prevention of progression of the disease by lowering the risk of acute urinary retention and the need for surgical intervention, and a statistically significant improvement in the state of the lower urinary tract, urinary flow rate and increase in prostate volume reduction compared to placebo. All the above mentioned changes over 24 months.

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Dutasteride is administered orally in soft gelatin capsules. After administration of a single dose of 0.5 mg of the maximum drug concentration observed in plasma after 1-3 hours. The absolute bioavailability is 60% and is independent of food intake.
Dutasteride after single or multiple receiving a large volume of distribution. The binding to plasma proteins> 99.5%.

When used in a daily dose of 60% of the equilibrium concentration Dutasteride constant plasma levels achieved after 1 month of treatment, and about 90% after 3 months.

Dutasteride constant equilibrium concentration of about 40 nH / ml is achieved in blood plasma after 6 months of receiving, at a daily dose of 0.5 mg.

Similarly, blood plasma constant equilibrium concentration Dutasteride in seminal fluid is achieved in 6 months.

After 52 weeks of treatment, the mean concentration in semen Dutasteride is 3.4 ng / ml (range 0,4-14 ng / ml). Dutasteride ratio of plasma distribution in the seminal fluid of about 11.5%.

In vitro Dutasteride is metabolized by CYP 450 3A4 enzymes of the cytochrome P450 mono person up to two hydroxy metabolites. The blood plasma according spectrometric analysis reveals unaltered dutasteride, 3 major metabolite (4-gidroksidutasterid, 1,2-dihydro-6 and Dutasteride gidroksidutasterid), 2 minor metabolite (6,4 and 1,5-dihydroxy Dutasteride gidroksidutasterid).

Dutasteride is extensively metabolized. Dutasteride after ingestion of 0.5 mg / day 1-15,4% (average 5.4%) is excreted in the feces as unchanged Dutasteride, rest - in the form of metabolites.

The urine is defined as follows unchanged Dutasteride <0,1%.

The final half-life Dutasteride is 3-6 weeks. Dutasteride Footprints in the blood plasma can be detected within 4-6 months after treatment.

INDICATIONS:

Treatment and prevention of the progression of benign prostatic hyperplasia, by reducing prostate size, decrease the severity of symptoms, improved urinary flow, reducing the risk of acute urinary retention and the need for surgical intervention.
In combination with tamsulosin - treatment and prevention of the progression of BPH by reducing prostate size, decrease the severity of symptoms and improve the flow of urine.

APPLICATION:

Avodart may be administered as monotherapy or in combination with an α-receptor blocker tamsulosin (0.4 mg).
Adult males (including the elderly).
The recommended dose Avodart - capsule 1 (0.5 mg) a day, orally.
The capsule is swallowed whole, not chewed or opened as contact with the capsule contents may result in irritation of the mucous membranes of the mouth and pharynx.

Avodart can be taken regardless of meals.
Despite the fact that the decrease in severity of symptoms can be observed after a short time after taking the drug for an objective assessment of the effectiveness of drug treatment should be continued for at least 6 months.

CONTRAINDICATIONS:

hypersensitivity to dutasteride, other inhibitors of 5-α-reductase, or other ingredients.
Severe hepatic insufficiency.
Avodart is not used in women and children!

Undesirable effects:
Immune system:

Very rarely - allergic reactions including rash, pruritus, urticaria, localized edema, and angioedema. Skin and subcutaneous tissue: rare - alopecia (hair loss mainly on the body), hypertrichosis. Erectile dysfunction.

Liver failure:
Farmokokinetika Dutasteride was not studied in patients with hepatic insufficiency.

Renal failure:
For patients with renal failure is not necessary to adjust the dose.

SPECIAL INSTRUCTIONS:

Dutasteride can be absorbed through the skin, therefore, women and children must avoid contact with leaking capsules. If the contents of the capsule with a horrible skin, immediately wash with soap and water.
Effect of hepatic impairment on the pharmacokinetics of Dutasteride has not been studied. Since Dutasteride buy is extensively metabolized, half-life period is 3-5 weeks. The drug is used with caution in liver disease.

Use in combination with tamsulosin:
According to the 4-year clinical study of heart failure frequency was higher among patients who were treated with a combination of Avodart α-adrenoceptor blockers mainly tamsulosin, compared with patients who were not treated with this combination.
According to two studies heart failure rate was low (<1%) within these studies. The imbalance in the incidence of cardio-vascular adverse events were not in any of the studies. there was no causal link between the use of Avodart (alone or in combination with an α-adrenergic blocker) and the occurrence of heart failure.
Effect on Prostate Specific Antigen (PSA) and prostate cancer detection.

Before the course Dutasteride treatment and periodically during treatment should be carried out a digital rectal examination of the patient and other studies for the detection of prostate cancer.
PSA concentration is an important component of a screening method for the detection of prostate cancer.
Avodart treatment capable of reducing the level of PSA in the blood plasma of benign prostatic hyperplasia by approximately 50% after 6 months of treatment. Patients who are treated of Avodart, should have a new baseline the PSA, established after 6 months of treatment. The PSA level is recommended to check regularly.

Any PSA levels steady increase in comparison with the minimum values ​​during treatment with Avodart may indicate the presence of prostate cancer (particularly high grade cancer) or non-reception mode Avodart and needs careful study, even if the PSA indicators are within the normal range for men, inhibitors which are not treated with 5-α-reductase.
Application Avodart not affect the use of PSA levels for the diagnosis of prostate cancer after it establish a new reference value. According to the 4-year clinical study with patients with an increased risk of prostate cancer, the increase in PSA level after establishing its new value (after 6 months of treatment) is more informative (especially for high grade cancer) in men who were treated Avodart by compared with those who took a placebo.
Total serum PSA levels return to baseline within 6 months after stopping treatment.
The ratio of free PSA and total PSA level remains constant even during Avodart treatment. Therefore, when used for the diagnosis of prostate percent free PSA in cancer patients receiving Avodart buy, free PSA is not a value to be doubled.
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Studying the influence Dutasteride at 0.5 mg per day on the characteristics 30 healthy volunteers over 52 weeks of treatment and 24 weeks of follow-up revealed a decrease in total sperm count, ejaculate volume and sperm motility by 23%; 26% and 18% compared to the changes in the placebo group.
Sperm concentration and its morphology remained unchanged. After 24 weeks of follow-up the mean percentage change in the total number of sperm in the Dutasteride group remained 23% below baseline.
While mean values ​​for all semen parameters at all times remained within normal limits and did not meet certain criteria for clinically significant changes (30%), 2 patients Dutasteride group noted a decrease in sperm count by more than 90% compared with baseline at week 52 of treatment, and partial reduction in their number at 24 weeks of follow-up.
The clinical significance of the effect of Dutasteride on semen characteristics for an individual patient fertility is unknown.

Dutasteride (Avodart) application for women:

Dutasteride is contraindicated for women. The use of Dutasteride for the treatment of women did not study, because according to the pre-clinical study suggested that the decline in circulating levels of DHT can lead to disruption of the development of external genitalia in male fetus.

Dutasteride (Avodart) application for children:

Children - Use Dutasteride is contraindicated!

When working with dangerous machinery:

The drug can affect the reaction rate while operating a vehicle or other machinery!
Given the pharmacokinetic and pharmacodynamic properties, Dutasteride has no effect on ability to drive and other mechanisms.

If you want to buy Dutasteride - before treatment consult your doctor.