How to buy Accutane online

On this page you will learn:

  1. Isotretinoin - reviews of dermatologists
  2. Isotretinoin - price, instructions for use
  3. Isotretinoin (Accutane) - where to buy / how to order

Isotretinoin (13-cis-retinoic acid) - is a structural analogue of vitamin A. Refers to the preparations of the retinoid group. It is used to treat acne, rosacea, dermatitis, as well as to reduce the depth of wrinkles and fine lines on the skin of the face.

Assign Accutane:

  • For the treatment of acne and acne;
  • To reduce the depth of wrinkles and signs of photoaging of the skin.

1. Isotretinoin for acne.

The mechanism of action of drugs based on Isotretinoin (Accutane) with acne:

Reduces the thickness of the surface layer of the epidermis:
when applied to the skin, isotretinoin has a weak irritant effect on the cells of the stratum corneum, causing them to peel and slough (peeling effect). This leads to a decrease in the thickness of the surface horny layer of the epidermis, consisting of dead cells. This makes the pores of the skin more open, which prevents the formation of pores in the pores of fatty plugs (blackheads).

Comedonic properties:
isotretinoin is able to dissolve the substance of fatty plugs that clog pores of the skin. This leads to the purification of the pores of the skin from acne, and also helps prevent the formation of acne.

Reduces the activity of the sebaceous glands:
one of the main factors for the formation of acne and acne is the increased function of the sebaceous glands, the ducts of which open into the lumen of the hair follicles that are in the pores of the skin. Increasing the production of fatty secretion helps to block the pores. Isotretinoin normalizes the function of the sebaceous glands of the skin, reducing their secretion.

Important: keep in mind that you will need about 4 weeks before you notice some positive changes on the skin. Therefore, be patient. In addition, the first 1-2 weeks may aggravation of your acne (this is normal when using this group of drugs).

2. Reducing the depth of wrinkles:

Applying preparations of the retinoid group to treat skin diseases, dermatologists found that the skin became also more elastic, smooth, and the depth of wrinkles decreased. These effects were investigated, and it turned out that Isotretinoin has the following effects on the skin.

Peeling effect:
application of the drug leads to a decrease in the thickness of the surface stratum corneum of the epidermis due to exfoliation of dead skin cells. This allows the skin to look more youthful and radiant, as if you performed several procedures of surface chemical peeling.

Increase the rate of division of stem cells of the epidermis:
isotretinoin affects stem keratinocytes (their numerous layers of these cells and the epidermis consists), increasing the rate of their division and transformation into mature keratinocytes. This leads to an increase in the thickness of the deep layers of the epidermis, consisting of living keratinocytes.

Increasing the thickness of the epidermis leads to an increase in its hydrophobic properties, which is expressed in the fact that the skin will lose less moisture as a result of reducing its evaporation from the surface of the skin. Well-moisturized skin always looks younger.

Stimulation of the production of collagen and hyaluronic acid:
isotretinoin penetrates not only in the epidermis, but also penetrates deeper layers of the skin. There he increases the production of his own collagen and elastin, as well as hyaluronic acid by stimulating the activity of fibroblasts. All this increases the elasticity of the skin, helps reduce the depth of wrinkles and fine lines on the face.

Optimal concentration of Isotretinoin to reduce wrinkles:
Studies have shown that Accutane, as an active ingredient in other creams and gels, has a beneficial effect on the treatment of photoaging of the skin.

We analyzed three main studies:

1) Armstrong RB, Lesiewicz J, Harvey G et al. Clinical panel assessment of photodamaged skin treated with isotretinoin using photographs. Arch Dermatol 1992; 128: 352-6. "
2) "Sendagorta E, Lesiewicz J, Armstrong RB. Topical isotretinoin for photodamaged skin. J Am Acad Dermatol 1992; 27: S15-18. "

In these studies, the concentration of Isotretinoin was increased from 0.05% at the beginning of the study to 0.1% at the end of the study. Despite the increase in concentration, the drug was well tolerated by patients, without causing significant skin irritation. As a result of treatment of photoaging of the skin with 0.1% isotretinoin, the effect of skin improvement gradually increased throughout the 36-week treatment.

3) The study "Maddin S, Lauharanta J, Agache P et al. Isotretinoin improves the appearance of photodamaged skin: results of a 36-week, multicenter, double-blind, placebo-controlled trial. J Am Acad Dermatol 2000; 42: 56-63. "In this study, a combination of 0.05% isotretinoin combined with sunscreens was used to treat photoaging. The result - the state of the skin with visible photodamage was significantly improved, which was recorded by profilometry.

Conclusion: if you are interested in the prevention of photoaging of the skin, it is best to use 0.05% concentration in combination with sunscreen. If you want to increase the elasticity of the skin and reduce the depth of wrinkles, then the main treatment should be carried out using 0.1% concentration, but for the adaptation of the skin to the drug in the first month or two it is better to apply 0.05% concentration.

The action of isotretinoin has a delayed effect - it will take about 8-12 weeks before you notice some positive changes. Therefore, be patient. The scheme of application of the drug to reduce wrinkles will be the same as for the treatment of acne.

SUMMARY: Is it worth to use isotretinoin against wrinkles?

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